منابع مشابه
Nitric oxide synthase genes: candidate genes among many others.
Because of the complex and multiorgan origin of hypertension, the genetic approach is the preferred strategy for discovering genes predisposing to the disease, a strategy that was successful mostly for monogenic forms of the disease. Both linkage studies in families with informative markers and case-control studies with biallelic markers or putative functional variants on candidate genes were w...
متن کاملMitochondrial nitric oxide synthase.
Nitric oxide (NO) regulates several cellular functions via reversible regulation of mitochondrial respiration. Nitric oxide also reacts with mitochondrial superoxide anion to produce the potent oxidative species peroxynitrite that irreversibly hinders mitochondrial activities. Recent findings demonstrating that mitochondria produce NO via mitochondrial NO synthase (mtNOS) has intrigued several ...
متن کاملNitric oxide/nitric oxide synthase, spermatogenesis, and tight junction dynamics.
During spermatogenesis, preleptotene and leptotene spermatocytes, residing in the basal compartment of the seminiferous epithelium, must traverse the blood-testis barrier (BTB) to gain entry to the adluminal compartment for further development at late stage VIII and early stage IX of the epithelial cycle. As such, the timely opening and closing of the BTB is crucial to spermatogenesis. A compro...
متن کاملNitric oxide produced by endothelial nitric oxide synthase promotes diuresis.
Extracellular fluid volume is highly regulated, at least in part, by peripheral resistance and renal function. Nitric oxide (NO) produced by NO synthase type 3 (NOS 3) in the nonrenal vasculature may promote fluid retention by reducing systemic vascular resistance and arterial pressure. In contrast, NO produced by renal NOS 3 promotes water excretion by reducing renal vascular resistance, incre...
متن کاملNitric oxide synthesis and nitric oxide synthase enzymes
Worldwide osteoarthritis (OA) affects more than 9.6% of men and 18% of women older that 60 years. Treatment for OA often requires chronic use of selective or nonselective nonsteroidal antiinflammatory drugs (NSAIDs), which have been associated with gastrointestinal and cardiovascular complications. An increased risk for upper gastrointestinal bleeding with NSAIDs alone and when combined with lo...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1999
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.33.4.924